Publications
Tolerogenic dendritic cells induce apoptosis-independent T cell hyporesponsiveness of SARS-CoV-2-specific T cells in an antigen-specific manner University of Antwerp
Chimeric antigen receptor transgenic, T cell receptor/CD3 negative monospecific T cells generated from cord blood CD34 positive cells Ghent University
An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8+ T cells Vrije Universiteit Brussel
Dendritic cell (DC)-maturation stimuli determine the potency of these antigen-presenting cells and, therefore, the quality of the T-cell response. Here we describe that the maturation of DCs via TriMix mRNA, encoding CD40 ligand, a constitutively active variant of toll-like receptor 4 and the co-stimulatory molecule CD70, enables an antibacterial transcriptional program. Besides, we further show that the DCs are redirected into an antiviral ...
Train your T cells: How skeletal muscles and T cells keep each other fit during aging Hasselt University
Activation of myelin reactive T cells in multiple sclerosis: A possible role for T cell degeneracy? Hasselt University
Functional characterization of in vivo effector CD4+ and CD8+ T cell responses in acute Toxoplasmosis : an interplay of IFN-gamma and cytolytic T cells. Vrije Universiteit Brussel
infected subjects are protected against secondary infection during pregnancy. CocktailDNAvaccines have
been shown to provide high resistance to parasite challenge, and latently infected mice are protected
against acute disease. In order to characterize the associated Th1 cellular immune responses in vivo, we
used H2-Kk ...
Tumor cells in multiple myeloma patients inhibit myeloma-reactive T cells through carcinoembryonic antigen-related cell adhesion molecule-6 Vrije Universiteit Brussel
Although functionally competent cytotoxic, T cells are frequently observed in malignant diseases, they possess little ability to react against tumor cells. This phenomenon is particularly apparent in multiple myeloma. We here demonstrate that cytotoxic T cells reacted against myeloma antigens when presented by autologous dendritic cells, but not by myeloma cells. We further show by gene expression profiling and flow cytometry that, similar to ...