Publications
Activation of myelin reactive T cells in multiple sclerosis: A possible role for T cell degeneracy? Hasselt University
Induction of cytomegalovirus-specific T cell responses in healthy volunteers and allogeneic stem cell recipients using vaccination with messenger RNA-transfected dendritic cells Vrije Universiteit Brussel University of Antwerp
BACKGROUND: Infection with human cytomegalovirus (CMV) is a significant cause of morbidity and mortality in solid organ and hematopoietic stem cell transplant (HSCT) recipients.
METHODS: The present study explored the safety, feasibility, and immunogenicity of CMV pp65 messenger RNA-loaded autologous monocyte-derived dendritic cells (DC) as a cellular vaccine for active immunization in healthy volunteers and allogeneic HSCT recipients. ...
Tolerogenic dendritic cells induce apoptosis-independent T cell hyporesponsiveness of SARS-CoV-2-specific T cells in an antigen-specific manner University of Antwerp
Functional characterization of in vivo effector CD4+ and CD8+ T cell responses in acute Toxoplasmosis : an interplay of IFN-gamma and cytolytic T cells. Vrije Universiteit Brussel
infected subjects are protected against secondary infection during pregnancy. CocktailDNAvaccines have
been shown to provide high resistance to parasite challenge, and latently infected mice are protected
against acute disease. In order to characterize the associated Th1 cellular immune responses in vivo, we
used H2-Kk ...
Chimeric antigen receptor transgenic, T cell receptor/CD3 negative monospecific T cells generated from cord blood CD34 positive cells Ghent University
1,25-Dihydroxyvitamin D3 and Its Analog TX527 Promote a Stable Regulatory T Cell Phenotype in T Cells from Type 1 Diabetes Patients KU Leuven Ghent University
An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8+ T cells Vrije Universiteit Brussel
Dendritic cell (DC)-maturation stimuli determine the potency of these antigen-presenting cells and, therefore, the quality of the T-cell response. Here we describe that the maturation of DCs via TriMix mRNA, encoding CD40 ligand, a constitutively active variant of toll-like receptor 4 and the co-stimulatory molecule CD70, enables an antibacterial transcriptional program. Besides, we further show that the DCs are redirected into an antiviral ...