Projects
Targeted tolerance in multiple sclerosis: development of transgenic T cell receptor-engineered regulatory T cells recognizing myelinderived antigens. University of Antwerp
Targeted tolerance in multiple sclerosis: development of transgenic T cell receptor-engineered regulatory T cells recognizing myelin basic proteins. University of Antwerp
The role of the Wiskott-Aldrich Syndrome protein (WASp) in human T cell development and on the development of the T cell repertoire. Ghent University
Using gene editing techniques, we will replace a healthy WAS gene in cord blood stem cells with a defectie WAS gene from patients. These stem cells will subsequently be differentiated to T cells in various models of T cell differentiation. In this way, we will acquire knowledge on what exactly is the role of the WAS protein during T cell differentiation and the generation of a diverse T cell repertoire.
Manipulation of human pluripotent stem cells for the study of normal T cell development and immune deficiencies Ghent University
The abstract for "178GE0713" is missing. Contact the promotor for more information
Identification of the molecular drivers of ab vs. gd T cell development at single cell resolution in human Ghent University
ab and gd T cells have distinct roles in the immune system but arise from common precursors in the thymus. Many details about their development are incompletely understood; in particular, how and when the ab vs. gd fate decision occurs during human T cell development is still being debated. The Taghon lab recently demonstrated that thymocytes committing to the gd but not the ab lineage undergo pronounced changes in chromatin accessibility. ...
Single cell approaches for the study of early human T cell development Ghent University
T lymphocytes are important blood cells within the immune system and are generated in the thymus from seeding hematopoietic precursor cells. In this project, we wish to use single cell techniques to identify and characterize these immigrating precursor cells, as well as the first stages of human T cell development.
Origin and molecular drivers of T cell and dendritic cell development in the human thymus. Ghent University
The immune system is our body’s major defense mechanism against invading pathogens, as well as against tumor cells. One of the critical white blood cells that plays a central role in the immune system comprises T lymphocytes. They are generated from blood forming stem cells that undergo a series of discrete developmental stages within a specific organ called the thymus. This organ controls their proper development and this is mediated by ...
Unraveling the structural and functional roles of THEMIS proteins in T cell and B cell development and inflammation Ghent University
The human immune system is a sophisticated defense mechanism which identifies invading pathogens and molecular challenges to coordinate their neutralization and removal Specialized cells known as T and B lymphocytes are key effectors of the adaptive immune response Lymphocyte development is tightly controlled to prevent the expansion of destructive, self-reactive T and B cells and the development of autoimmune diseases Themis1 and Themis2, ...
Defining the molecular netwerk responsible for human T cell development Ghent University
Following our longstanding interest in the development of T lymphocytes, we aim to study the role
and the interplay of transcription factors in human T lymphocyte development. T lymphocytes are
cells of the adaptive immune system that play a crucial role in the protection against pathogens and
tumor cells. Although T cells are derived from hematopoietic stem cells that reside in the bone
marrow, they undergo a series of ...