Breaking down the molecular code directing specific synaptic connectivity in hippocampal circuits. KU Leuven
Neurons in the brain are interconnected with striking precision. The specificity of connectivity is crucial for correct neural function, as aberrant connectivity contributes to diseases such as epilepsy. However, there is a notable lack of knowledge on how synaptic connections are specified during development. CA1 pyramidal dendrites show an exquisite synaptic specificity: inputs from different brain areas are segregated in distinct dendritic ...