New genetic systems with four synthetic nucleobases: towards advance therapy and synthetic biology KU Leuven
Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are among the most remarkable biomolecules occurring in nature since they store and transfer all genetic information using only four letters (G, C, A & T or U) of the genetic alphabet. After the discovery of the structure of nucleic acids, numerous chemically modified nucleosides and nucleotides have been produced and incorporated into oligomeric sequences, either by chemical or ...