Cancer cells and their microenvironment: from gene regulatory networks to therapy Ghent University
It is now generally accepted that the tumor and its microenvironment (i.e., the stroma) cross-talk to each other at multiple levels to elicit carcinogenesis, invasion and progression to metastasis. In addition to the well-established stepwise accumulation of somatic genetic alterations in tumor cells, it has now become clear that genetic and (epi)genomic alterations that play an important role in the development and/or progression of (solid) ...