The role of 'endoplasmic reticulum (ER) stress' and the 'integrated stress response' in the pathogenesis of hepatic encephalopathy (HE): Exploring the therapeutic potential of ER stress modulation in HE. Ghent University
Hepatic encephalopathy (HE) describes the deterioration of brain function in patients with acute or chronic liver failure. This entity, typified by cognitive, behavioral and motoric deficits, relates to neuronal death, the origin of which is unknown in HE. About 80% of patients suffering from liver cirrhosis are at risk to develop HE, resulting in high morbidity and mortality, reduced quality of life and a high economic burden. Current ...