Streptomycin resistance and lineage-specific polymorphisms in Mycobacterium tuberculosis gidB gene Institute of Tropical Medicine
Mutations related to streptomycin-resistance in the rpsL and rrs genes are well known and can explain about 70% of this phenotypic resistance. Recently, the gidB gene was found to be associated with low level streptomycin-resistance in Mycobacterium tuberculosis. Mutations in gidB have been reported with high frequency, and this gene appears to be very polymorphic, with frameshift and point mutations occurring in streptomycin-susceptible and ...