Projects

STREPSYNTH aims to set-up a Streptomyces-based new industrial production platform (SNIP) for high value added biomolecules. Streptomyces lividans was chosen as a bacterial host cell because it has been already shown to be highly efficient for the extracellular production of a number of heterologous molecules that vary chemically, has a robust tradition of industrial fermentation and is fully accessible to genetic intervention. To develop SNIP ...

For the recombinant production of industrial enzymes, therapeutic proteins, bioactive molecules, a.o., a variety of host cells is known in the industrial biotech. Host selection dependent on the cell's expression range, the yield, production costs, etc. No single host is suited for every component or every production process. Streptomyces lividans TK24 is an interesting host because of its high secretion capacity, low endogenous ...

White biotechnology has demonstrated a vast growth during the last decade, mainly thanks to its sustainable advantages compared to classical chemical processes. To maintain this growth, different micro-organisms are being studied as potential cell factories. Among these micro-organisms, Streptomyces lividans has received increasing attention as a host for the production of heterologous proteins. To enable rational strain improvement ...

Mycotoxins are toxic molecules produced by fungi which can contaminate crops on the field aswell as food and feed stocks during storage. Consuming contaminated food or feed is harmful toboth humans and animals. To combat this issue, farmers and feed pro

Lignocellulosic biomass is believed to be the most promising renewable feedstock for sustainable production of biofuels and commodity chemicals in biorefineries. While the need for sustainable systems is continuously increasing, the depolymerization of lignocellulose is impeded by its high recalcitrance. This makes the development of a cost-effective process extremely challenging. In enzymatic degradation, the classical view of synergistic ...

The diketopiperazine scaffold is a preferred (sub)structure in a wide variety of physiologically active natural compounds, including brevianamide F (antibacterial), present in Streptomyces and Aspergillus species. The project aims at the synthesis of heterodiketopiperazine analogues with a less complicated structure than the active natural compounds or the synthesis of diketopiperazines with medicinal relevant substituents starting from amino ...