Projects
Kernel Based Methods for Microarray and Mass Spectrometry Data Analysis KU Leuven
Microarray and mass spectrometry data sources measure the activity and/or expression of thousands of genes and proteins, respectively, on a given set of biological samples. Analysis of the information contained in such samples has become a crucial activity in cancer research during the ...
Algorithms for Analyzing Biological Sequences KU Leuven
Precision measurements of the electron energy distribution in nuclear beta decays KU Leuven
Although nuclear β decays have been studied for almost a century, there are still questions that can be answered through precision measurements of the energy distribution of emitted electrons. The shape of the β spectrum reflects not only the weak interaction responsible for the decay. It is also sensitive to the strong interaction which confines the decaying quark in the nucleon. The electromagnetic force also plays a role since the ejected ...
Strategic Research Programme: Exploiting the Advantages of Order and Geometrical Structure for a Greener Chemistry Vrije Universiteit Brussel
Development of non-destructive analysis protocols for the chemical and isotopic analysis of archaeological materials KU Leuven
New analysis protocols for the non-destructive chemical analysis of ancient materials will be developed. Micro - X-ray fluorescence (µXRF) will be used to look at major to trace element compositions. Laser ablation – multi collector - inductively coupled plasma - mass spectrometry (LA-MC-ICP-MS) will be used to perform isotopic analysis, focusing on Pb-Sb-Sr-Nd isotope ratios. Protocols will be developed, for both methods, custom-made to the ...
Insight into non-enzymatic browning in shelf-stable orange juice during storage KU Leuven
Non-enzymatic browning (NEB) is an important quality defect during storage of shelf-stable fruit juices including orange juice. NEB in pasteurized shelf-stable orange juice is hypothesized to be due to chemical reactions involving the degradation of ascorbic acid and/or sugars. Nevertheless, the mechanism of NEB is still not fully elucidated. Until today, NEB is a shelf-life limiting factor of shelf-stable fruit juices. Therefore, there is a ...
Modeling, automatisation and optimisation of experimental processes in network-structured domains. KU Leuven
In a lot of research fields such as biology, medicine and sociology, experiments are used to learn about the domain of interest. Such experiments are often complex processes and the interpretation of their result should happen in the context of the related knowledge in the domain. A major challenge is to perform the research efficiently, using a minimum of resources to achieve a maximum of new knowledge. This project aims at addressing this ...
ULB-VUB Joint Research Group: Brussels (Bio)Pharmaceutical Analysis Research Group - BBRG Vrije Universiteit Brussel
In this regard, the development of ...
ENDOTHELIAL PKA ACTIVITY REGULATES ANGIOGENESIS BY LIMITING AUTOPHAGY THROUGH PHOSPHORYLATION OF ATG16L1 KU Leuven
The cAMP-dependent protein kinase A (PKA) regulates a plethora of cellular functions in health and disease. During angiogenesis, PKA activity in endothelial cells controls the transition from sprouting to vessel maturation and limits tip cell formation independently of Notch signaling. The molecular PKA targets mediating these effects remain unknown. We report a chemical genetics screen identifying endothelial-specific substrates of PKA in ...