Nucleoside analogues for the treatment of parasitic infections Ghent University
The invention relates to the tubercin analogues showing potential against either T.brucei (sleeping sickness) or T.cruzi (Chagas disease). Our invention beholds the discovery of two series of (deaza)purine analogues that show very potent inhibition of parasite growth in vitro. In a proof-of-concept animal model the compounds showed non-inferior efficacy with respect to the reference drug, suramin (which is clinically used for stage I Human African Trypanosomiasis (HAT)). Additionally, as other parasites might also be sensible to some of these analogues, a multi-targeting derivative could be ...