Projects
Intermittent exogenous ketosis during exercise and training: exploring the role of de novo angiogenesis and epigenetic regulation in muscular adaptation KU Leuven
We recently demonstrated intermittent exogenous ketosis (IEK) by oral ketone ester intake to stimulate angiogenesis during muscular overload. IEK also inhibited muscle deterioration in a mouse model of cancer cachexia. This project aims to investigate the role of angiogenesis and epigenetic modification in the effects of IEK on exercise-induced muscular remodeling. In vitro experiments involve incubation of myoblasts and endothelial cells ...
INTERMITTENT EXOGENOUS KETOSIS DURING EXERCISE AND TRAINING: EXPLORING THE ROLEÂ OF DE NOVO ANGIOGENESIS AND EPIGENETIC REGULATION IN MUSCULAR ADAPTATION KU Leuven
Towards a better selection of systemic treatment for patients with ER-positive HER2-negative breast cancer: the use of prognostic and predictive markers in early and metastatic setting KU Leuven
Worldwide, breast cancer represents about 25% of all cancers in women. There is extensive research effort into this highly complex and heterogeneous disease comprising many different histological and molecular subtypes with luminal, oestrogen receptor (ER)-positive human epidermal growth factor receptor 2 (HER2)-negative tumours being the most frequent subtype. Even within this subtype, there is a lot of heterogeneity, which complicates ...
Prokaryote proteomics at high temperature for single cells. Flanders Institute for Biotechnology
Profiling of the colorectal tumor (CRC) immune microenvironment (TME) to identify novel therapeutic opportunities and biomarkers KU Leuven
Immune checkpoint inhibition (ICI) is an existing therapeutic approach for the treatment of cancer. Whereas immune checkpoint blockade has been used successfulle for a variety of tumor types, only a small portion of colorectal tumors can be treated with this approach. Therefore, cellular composition and molecular features of ICI-therapy responsive and resistant colorectal tumors is important to understand the underlying mechanisms. We propose ...
Genetic and biochemical analysis of neural circuit formation. KU Leuven
Genetic and biochemical analysis of neural circuit formation.
NXT-EYE: integrative strategy and identification of hereditary blindness Ghent University
Inherited retinal diseases (IRD) are a major cause of early-onset blindness, having an overall prevalence of ~1/3,000. In addition to the wide spectrum of different clinical subtypes, IRD are also characterized by a tremendous genetic heterogeneity. Up to now, molecular genetic studies have identified 256 genes listed in RetNet that are associated with IRD, complicating the establishment of a molecular genetic diagnosis. Recent genetic ...
MICRO-TOX: Unravelling the in vitro toxic effects of the mycotoxin beauvericin, bacterial toxin cereulide and cyanobacterial microcystins, and their interactions with co-exposed microplastics Ghent University
Over the lifetime, humans are exposed to an infinite number of toxic chemical contaminants present in the foods and environment. In the past, researchers were focusing on single or a group of similar toxins in order to understand their harm on the body. However, this does not reflect the toxic effects of the real co-exposure to several food and environmental contaminants on the body. Currently, the effects of exposure to a complex mixture of ...
Detection of somatic mutations and disease-defining methylation patterns in brain tissue and cerebrospinal fluid of patients with non-acquired focal epilepsy Ghent University
The majority of non-acquired focal epilepsies (NAFE) have a presumed genetic etiology. However, the current yield of diagnostic genetic testing in affected patients is very low. This diagnostic gap is an important barrier to the broader use of gene-targeted therapies. Increasing evidence from resected brain tissue of individuals with NAFE points towards an important role of pathogenic somatic variants and methylation abnormalities. Most NAFE ...