Study of crosstalk between GPCR-mediated signals and the NF-kappaB signal transduction cascade. Ghent University
Nuclear Factor κB (NF-κB) is a ubiquitously expressed transcription factor for genes involved in inflammation. The transcription of NF-κB-dependent genes can be altered by crosstalk with other signaling pathways. Recently, it has become evident that G-protein-coupled receptors (GPCRs) are implicated in immunity and that there is connectivity with NF-κB signaling. One of the GPCRs, that has received a lot of attention in the field of ...