Publications

Chosen filters:
Chosen filters:

1 - 10 of 21 results

Sorteren op
Search term:

Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the 3.7 triplication in congolese patients than in worldwide series KU Leuven

Koenraad Devriendt, Gert Matthijs
BACKGROUND: Information about the association with alpha thalassemia in sickle cell patients is unknown in the Democratic Republic of Congo. There is very little data on the alpha thalassemia in patients suffering from sickle cell anemia in Central Africa, and their consequences on the clinical expression of the disease. METHODS: A cross-sectional study was conducted in 106 sickle cell patients living in the country's capital Kinshasa. The ...

The interaction between sickle cell disease and HIV infection: a systematic review Institute of Tropical Medicine

Benjamin Jelle Visser, Petra F Mens, Martin P. Grobusch

Human immunodeficiency virus (HIV) and sickle cell disease (SCD) are regarded as endemic in overlapping geographic areas; however, for most countries only scarce data on the interaction between HIV and SCD and disease burden exist. HIV prevalence in SCD patients varies between 0% and 11.5% in published studies. SCD has been suggested to reduce disease progression of HIV into AIDS. Various interactions of antiretroviral therapy with SCD exist. ...

GENETIC MODULATORS OF SICKLE CELL DISEASE IN THE DEMOCRATIC REPUBLIC OF CONGO KU Leuven

Mamy Ngole Zita
Sickle cell anemia (SCA) is the most common hemoglobinopathy worldwide. Developing countries like the Democratic Republic of Congo (DRC) suffer a heavy burden and the disease-related mortality remains high, up to 50% to 90% before five years of age. Factors that contribute to high mortality include delayed diagnosis due to the scarcity of appropriate laboratory infrastructure, poor access to adequate medical care due to limited financial ...

Effect of poloxamer 188 vs placebo on painful vaso-occlusive episodes in children and adults with sickle cell disease University of Antwerp

James F. Casella, Bruce A. Barton, Julie Kanter, L. Vandy Black, Suvankar Majumdar, Adlette Inati, Yasser Wali, Richard A. Drachtman, Miguel R. Abboud, Yurdanur Kilinc, et al.
Key PointsQuestionCan poloxamer 188, an agent that is reported to reduce blood viscosity and cell-cell interactions, effectively reduce the duration of vaso-occlusive episodes (painful crises) in hospitalized patients with sickle cell disease? FindingsIn this randomized clinical trial that included 388 children and adults with sickle cell disease, treatment with poloxamer 188 vs placebo resulted in mean time to last dose of parenteral opioids ...

Varied age of first presentation of sickle cell disease : case presentations and review Ghent University University of Antwerp

Susanne Van Steijn, Lydia Van Kesteren, Elizabet Damen, Machiel Van den Akker
Sickle cell disease is a multisystem condition characterized by hemolytic anemia and vasoocclusion. Not only are the symptoms of the first presentation but also the ages of presentation are very variable. Following three case reports, different causes of possible late presentation are discussed. Many factors are responsible for the age at which sickle cell disease is diagnosed: doctor's delay (unfamiliarity with the disease), patient's delay ...

SERS biosensing of Sickle cell hemoglobin from Normal hemoglobin Vrije Universiteit Brussel

Sara Abbasi, Bastian Carnero Groba, Ilse Weets, Qing Liu, Francesco Ferranti, Prof. Dr. Ir. Heidi Ottevaere

Hemoglobinopathies are the most common genetic disorders caused by a mutation in the genes encoding for one of the globin chains and leading to structural (hemoglobin [Hb] variants) or quantitative defects (thalassemias) in hemoglobin. Early diagnosis and characterization of hemoglobinopathies are essential to avoid severe hematological consequences in the offspring of healthy carriers of a mutation. Despite being extensively studied, ...

Systematic Review of Genetic Modifiers Associated with the Development and/or Progression of Nephropathy in Patients with Sickle Cell Disease KU Leuven

Veerle Labarque
Sickle cell nephropathy (SCN) is a common complication of sickle cell disease (SCD) that significantly contributes to morbidity and mortality. In addition to clinical and life-style factors, genetic variants influence this risk. We performed a systematic review, searching five databases. Studies evaluating the effect of genetic modifiers on SCN were eligible. Twenty-eight studies (fair-to-good quality) were included: one genome-wide association ...

Red blood cell specifications for patients with hemoglobinopathies : a systematic review and guideline Ghent University

Veerle Compernolle, Stella T Chou, Susano Tanael, William Savage, Jo Howard, Cassandra D Josephson, Isaac Odame, Christopher Hogan, Gregory Denomme, Nadine Shehata, et al.
BACKGROUND: Red blood cell (RBC) transfusions remain essential in the treatment of patients with sickle cell disease (SCD) and -thalassemia. Alloimmunization, a well-documented complication of transfusion, increases the risk of delayed hemolytic transfusion reactions, complicates crossmatching and identifying compatible units, and delays provision of transfusions. Guidance is required to optimize the RBC product administered to these patients. ...