Projects
Impact of diagnostic delays and short treatment regimens on outcomes of rifampicin-resistant tuberculosis patients in Cameroon KU Leuven
Rifampicin-resistant tuberculosis (RR-TB) remains a major health challenge in low- and middle-income countries despite availability of diagnostic platforms and treatment options. Despite, increasing, increasing use of rapid molecular tests (e.g., Xpert MTB/RIF or Ultra) for detection of RR-TB globally, there is still a major RR-TB diagnostic gap and low treatment success of those started on treatment. Short injectable-containing regimens ...
Impact of diagnostic delays and short treatment regimens on outcomes of rifampicin-resistant tuberculosis patients in Cameroon Institute of Tropical Medicine
Top-level sport and post- secundary education in the Brussels-Capital Region Vrije Universiteit Brussel
The goal of this project is to develop ...
Top sport and higher education in the Brussels-Capital Region Vrije Universiteit Brussel
Rehabilitation after liver transplantation KU Leuven
Liver transplantation constitutes the only curative treatment for patients with end-stage liver disease. Advances in the field have led to favourable short- and medium term (1-3 year) post-transplant survival rates, but improvement in long-term survival rates remains disappointing. Due to the immunosuppressive therapy, a sedentary lifestyle and a poor recovery of post-transplant physical fitness, the proportion of liver transplant recipients ...
Home-based physical rehabilitation after liver transplantation and impact of exercise intensity: a randomized controlled trial KU Leuven
Liver transplantation constitutes the only curative treatment for patients with end-stage liver disease. Advances in the field have led to favourable short- and medium term (1-3 year) post-transplant survival rates, but improvement in long-term survival rates remains disappointing. Due to the immunosuppressive therapy, a sedentary lifestyle and a poor recovery of post-transplant physical fitness, the proportion of liver transplant recipients ...
Drug response profiling of T-cell acute lymphoblastic leukemia to optimize salvage therapeutic strategies for refractory/relapsed patients Ghent University
T-cell acute lymphoblastic leukemia (T-ALL) is a rare aggressive hematological malignancy that is
characterized by the diffuse infiltration of the bone marrow by malignant T-cell progenitors. Due to the
introduction of intensified combination chemotherapy, the prognosis of T-ALL has significantly improved
over the last years, with current protocols reaching cure rates over 80% in children and about 50% in
adults. ...
Pharmacometric models to improve therapeutic drug monitoring of monoclonal antibodies in the treatment of inflammatory bowel diseases KU Leuven
Inflammatory bowel diseases (IBD) are chronic, relapsing, inflammatory conditions of the gastrointestinal (GI) tract. Ulcerative colitis (UC) and Crohn’s disease (CD) are the primary subtypes of IBD. Although the etiology remains incompletely understood, it is generally accepted that IBD is the result of an inappropriate host response to environmental factors in genetically susceptible individuals. In Western Europe, prevalence of UC is ...
Boosting beta-cell function for treatment of type 1 diabetes KU Leuven
In type 1 diabetic (T1D) patients the pancreatic insulin-producing beta cells are selective destroyed by the immune system, leading to an impaired glucose metabolism. The steep increase in the incidence of this chronic autoimmune pathology especially in young children in the last decades raises serious concerns. To date, insulin therapy is considered the gold standard for the treatment of T1D. Nevertheless, limitations persist, such as the ...