ANTIBACTERIAL DOSING IN SPECIAL PATIENT POPULATIONS WITH SEVERE BACTERIAL INFECTIONS: A PATIENT-ORIENTED AND COVARIATE-DRIVEN APPROACH KU Leuven
Early and appropriate antibiotic therapy are crucial determinants for successful treatment of severe bacterial infections. Suboptimal antibiotic exposure has been shown to lead to worse clinical outcome (e.g., prolonged antibiotic course, prolonged length of stay, increased mortality). Hence, antibiotic exposure should be high enough to maximize the likelihood of clinical success, but not too high to avoid unnecessary toxicity. Beta-lactams ...