Projects

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Feasible self-assembly models Hasselt University

Jan VAN DEN BUSSCHE
Databases and Theoretical Computer Science
Self-assembly is the process in which intricate structures are obtained by spontaneous assembly of smaller building blocks. Self-assembly is present in a wide range of processes, and appears at various scales in nature. For example, the spontaneous formation of a molecular crystal and even the development of a sin- gle cell to a full-grown multicellular organism may be seen as (highly-involved) self-assembly processes. Self-assembly techniques ...

Fault tolerance in self-assembly models Hasselt University

Jan VAN DEN BUSSCHE
Databases and Theoretical Computer Science
Self-assembly is the spontaneous assembly of simple building blocks into intricate structures, and takes place both in nature and artificially. Because artificial top-down construction is becoming increasingly problematic when operating on smaller scales, self-assembly is fundamental for nanotechnology. In nature, self-assembly appears at virtually all scales: from, e.g., the spontaneous folding of RNA molecules via the development of single ...

Self-assembly of organic donor-acceptor complexes within the confinement of a perovskite lattice: a fundamental study of the relation between structure and opto-electronic properties. Hasselt University

Dirk VANDERZANDE
Materials Physics, Materials Chemistry
The main objective of this project is to achieve a fundamental insight in the structure and properties of 2D layered hybrid organic-inorganic perovskites with incorporated organic semiconductors and organic charge-transfer complexes derived from them by intercalation of organic acceptor molecules. The challenge is to merge in one single framework the best of two worlds, namely the versatility of organic semiconductors and organic charge-transfer ...

A comprehensive model of job search behavior: An integration of the Motivational Self -Regulatory Model and the Theory of Planned Behavior. Ghent University

Filip Lievens
Department of Work, Organisation and Society

The research project aims to theoretically build and empirically test a comprehensive model of job search behavior, integrating the Motivational Self-Regulatory Model and the Theory of Planned Behavior to identify the predictors of job search behavior. In addition, recent insight on the unfolding sequence of job search success are applied to add employment outcomes to the integrative model.

On-target assembly of druglike small molecules: a bottom-up approach using urokinase plasminogen activator and caspase 1 as model targets. University of Antwerp

Pieter Paula Frans Van Der Veken
Medicinal Chemistry (UAMC)
1) Current status in drug discovery methodology There are four commonly used approaches for the generation of "hits" and "leads" in contemporary drug discovery: (1) Structure-Activity-Relationship (SAR) research on high throughput screening (HTS) data, (2) transformation of endogenous ligands into druglike compounds, (3) in silico drug design and (4) fragment-based design. Due to the absence of a single eminent strategy, drug discovery projects ...

On-target assembly of druglike small molecules as protease inhibitors: a bottom-up approach using urokinase plasminogen activator (uPA) as a model target. University of Antwerp

Pieter Paula Frans Van Der Veken
Medicinal Chemistry (UAMC)
Common to all contemporary drug discovery strategies is that they revolve around iterative cycles of design, synthesis and potency evaluation, each time producing further optimized compounds. This is generally a very time- and cost-consuming process that could be significantly shortened by implementing so-called "on-target" strategies. The latter rely on direct assistance of the drug target, which serves as a physical template that selects ...

Developmental Trajectories of Non-Suicidal Self-Injury (Disorder) throughout Adolescence and Emerging Adulthood: An Integrative Model of Personality and Identity in Community and Clinical Samples. KU Leuven

Laurence Claes
Clinical Psychology, School Psychology and Development in Context

Non-suicidal self-injury (NSSI) is defined as ‘the direct, deliberate destruction of one’s own body tissue without suicidal intent’ and constitutes a significant public health problem. Common NSSI methods include cutting, burning, and hitting oneself. Research suggests that the occurrence of NSSI is still increasing, especially among adolescents and young adults. NSSI is associated with negative mental health outcomes, including anxiety, ...

Unified Physics-Based Model of Degradation of FinFETs and Nanowire FETs for beyond 7 nm Technologies KU Leuven

Guido Groeseneken
ESAT - MICAS, Microelectronics and Sensors

In the semiconductor industry, the trend of 3D integration brings new reliability challenges, especially for complementary horizontal stacked or vertical nanowires. Nanowire transistors with very short channels, operating in the near-ballistic regime, are expected to undergo severe hot-carrier degradation, resulting in charging of preexisting defects in the gate dielectrics and simultaneous generation of new defects. This will be compounded ...

Gender norms present barriers and fences in combining work and family: A process model of threat and self-regulation in non stigmatized identities. KU Leuven

Batja Gomes de Mesquita
Social and Cultural Psychology

Gender inequalities in the work and family domain persist. So far, most research investigated why women are underrepresented in the work domain and men in the family domain. In the current project, we shift focus to the parallel question: why are women overrepresented in the family domain and men in the work domain? We outline how women’s choices for family and men’s choices for work may not only be a result of their urge to pursue personal ...

Epigenetic regulation of differentiation of hepatocytes using human pluripotent stem cells as a model. KU Leuven

Catherine Verfaillie
Stem Cell and Developmental Biology

Pluripotent stem cells present in the inner cell mass of the blastocyst, from which embryonic stem cells (ESCs) are derived, self-renew while retaining the capability to differentiate to all cell types of the three germ layers. hESCs have a unique epigenetic state to maintain pluripotency (PMID: 21876557). During embryological development, pluripotent stem cells differentiate, governed by epigenetic changes that induce activation and ...