Dual function of SDS22 in the biogenesis of protein phosphatase-1 holoenzymes KU Leuven
Malignant mesothelioma is an aggressive cancer of the pleura and peritoneal cavities with limited treatment options. We have recently discovered that the pulse phosphorylation of protein kinase BUB1 functions as a timer for mitotic duration. In addition, this ‘BUB1 timer’ sensitizes cancer cells to anti-mitotic drugs and key components of the timer coordinate the (post)mitotic response to DNA-damage. Our objective is to explore whether the ...