Screening for drivers and dependency factors in a novel genetic model for T-ALL in Xenopus tropicalis Ghent University
Acute lymphoblastic leukemia (ALL) is an aggressive tumor entity of highly proliferative malignant
lymphoid cells. This leukemia subtype is one of the most common childhood malignancies
worldwide. T-ALL is a particularly aggressive hematologic cancer resulting from the malignant
transformation of T-cell progenitors. Despite our good and improving understanding of the
genomic defects in human T-ALL, leukemia patients ...