A high-throughput platform for screening amyloid strains and their seeding capacity at single-particle resolution KU Leuven
The development of recent methods, such as cryo-electron microscopy, has had a great impact on our understanding of amyloid aggregates. Despite this recent influx of structural information, however, we still do not fully understand how differential intrinsic properties of amyloid strains/conformers, such as their morphology, co-aggregation potential and transmissibility barriers relate to selective cellular/tissue toxicity and aggregation ...