Projects
Association of functional variations in brain-expressed miRNA genes with bipolar disorders and schizophrenia University of Antwerp
Synthesis and (pre)clinical evaluation of PET radioligands for in vivo visualization of phosphodiesterase 10, an enzyme involved in neurological and psychiatric disorders. KU Leuven
Longitudinal in vivo follow-up of PET biomarkers in neurological disease models. University of Antwerp
The experience of reality in psychosis Ghent University
Delusions in schizophrenia are commonly approached as empirical false beliefs about everyday reality. Phenomenological accounts, by contrast, have suggested that delusions are more adequately understood as pertaining to a different kind of reality-experience. To date, however, the specific nature of delusional reality-experience has not been subject to systematic empirical study. It is also unclear how this alteration of reality-experience ...
Transposable elements-mediated gene regulatory networks of brain diseases Ghent University
In recent years, it has become clear that transposable elements are not just part of the ‘junk’ DNA, but exert several functions and are implicated in several human diseases. Through using multi-omics data and gene regulatory networks, we will elucidate the role of transposable elements in the brain diseases schizophrenia and glioblastoma multiforme, for which effective treatment is still lacking.
Molecular keys in microglia to control neuronal wiring. Hasselt University
Psychiatric vulnerability among residents in residential care homes Odisee vzw
Nicotinic modulation of brain physiology and cognition in human aging. Hasselt University
Micro-mechanisms of anhedonia, and its consequences for future mental health KU Leuven
Anhedonia, one of the two core symptoms of Major Depressive Disorder (MDD), is defined as the loss of interest or pleasure in daily activities that were previously enjoyed (American Psychiatric Association, 2013). Although this definition fits clinicians’ needs, scientifically, we know very little about anhedonia.
So far, research indicated that nearly 1 in 5 individuals experience at least one episode of anhedonia during adolescence ...