Projects
A TRiP to the dorsal root ganglia: Unraveling the molecular characterization of the still neglected satellite glial cells. KU Leuven
Despite the classical neurocentric view on pain transmission, robust emerging evidence shows the critical role of other cell types on acute and chronic pain. Satellite glia cells (SGCs), found in the dorsal root ganglion, directly influences the development of hyperalgesia. However, the specific mechanisms by which SGCs contribute to pathological pain remains poorly understood. The central aim of this project is to elucidate the role of TRP ...
The role of TRPM3 in the development of pathological pain - from the periphery to the brain KU Leuven
Acute pain is a natural alarm response, which alerts us for potential injury, and motivates actions to protect affected body parts. However, in chronic pain patients, pain outlasts its alarm function and becomes a disease unto itself. An estimated 20% of the population suffer from moderate-to-severe chronic pain, with strong impact on health and wellbeing and immense societal costs. Pharmacological treatments are often unsatisfactory: ...