Targeting soft tissue sarcoma with smart molecules - exploring cytotoxic prodrugs and target-specific inhibitors in patient-derived xenografts KU Leuven
Soft tissue sarcomas (STS) are malignant tumours that originate in soft tissues, which connect, support and surround body structures and include for example muscle and fat. STS are a group of very diverse and rare tumours. Most STS have an aggressive behaviour, especially if diagnosed when the disease is in a more advanced stage. The current systemic standard therapies have very unsatisfactory effects in most subtypes of STS, with 1-year and ...