Dissecting the role of human astroglia in Alzheimer’s disease pathogenesis KU Leuven
In contrast to neurons, astrocytes are not very well investigated in Alzheimer’s disease (AD). This is remarkable: the most important genetic risk factor for AD is ApoE4 which is mainly expressed by these cells. Moreover, astrocytes are the most numerous cell type in brain and are affected at the early stages of the disease. The current understanding of astrocyte physiology is almost entirely restricted to observations in rodent models. ...