Can induced pluripotent stem cells from frontotemporal dementia be used to characterize mechanisms underlying progranulin haploinsufficiency mediated neurodegeneration? KU Leuven
Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral changes and language difficulties. Unlike other forms of dementia, FTD generally affects younger people and is heritable in many cases, with mutations in three genes (GRN, MAPT and C9orf72) explaining the majority of genetic cases. Autosomal dominant loss-of-function mutations in progranulin (GRN) induce haploinsufficiency ...