Pathogenesis of STAT1 gain-of-function and evaluation of gene therapeutic approaches. KU Leuven
Primary immunodeficiencies (PIDs) have provided crucial information
for the elucidation of immunological pathways. Although many causal
mutations in PID patients have been identified, the exact
pathogenesis often remains to be elucidated and clues for an
individualized therapeutic approach remain absent. In this project we
focus mainly on adult patients with a proven primary
immunodeficiency due to STAT1 ...