A profound study of the mechanism and field of application of the increase of Glucocorticoid Receptor transcriptional activity by zinc. Ghent University
We aim to find a treatment for systemic inflammatory response syndrom (SIRS), which is an often fatal acute condition occuring after serious trauma, bleeding, burning and infection (sepsis). Despite SIRS is an inflammatory condition, anti-inflammatory glucocorticoids (GCs) have no therapeutic benefit in SIRS. GCs bind to the GC receptor GR. Our work in mouse SIRS models show that GCs might have therapeutic future in SIRS if we find a way to ...