Projects
Drug delivery systems and in vivo efficacy of the serine protease inhibitor UAMC-00050 in a preclinical model for irritable bowel syndrome. University of Antwerp
Optimization of the synthesis of diarylphosphonate inhibitors of serin proteases using reaction calorimetry. University of Antwerp
Design, Synthesis and Biochemical evaluation of novel serine protease activity-based probes. University of Antwerp
Serthera: locking and monitoring of serine protease activity as the technological base for development of new and innovative drug candidates. University of Antwerp
Study of the protease inhibitor induced adaptation in two pest insects. KU Leuven
Synthesis of novel fluorescently quenched activity-based probes for serine proteases and the application in live cell imaging using various detection techniques KU Leuven
For its immune system to function properly, the human body relies on a multitude of signaling processes executed by many different types cells. The most common one of these cell types is the neutrophil. Neutrophil cells patrol the blood and once encountering pathogens, they react to kill it making use of their armory contained in different types of granules. The neutrophil serine proteases are an important part of this armory and they can, ...
Characterization and evaluation of monoclonal antibodies exhibiting differential effects on the activation of thrombin activatable fibrinolysis inhibitor and characterization and evaluation of nanobodies stimulating its zymogen activity. KU Leuven
The role of mucosal mediators and their effect on neuronal afferent signalling and intestinal permeability during postinflammatory visceral hypersensitivity: a translational study. University of Antwerp
Structural analysis of antibody-based profibrinolytics KU Leuven
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor superfamily, is the main physiologic inhibitor of plasminogen activators (PAs). Therefore, PAI-1 carries a flexible reactive center loop (RCL) that presents a substrate-mimicking peptide sequence that inserts into the active site of the PA. After initial complex formation, the reactive center in the RCL is cleaved by the PA which induces a conformational ...