Projects
Unravelling the molecular architecture of epilepsies by applying high-throughput sequencing technologies and functional assays on recessive kinships from isolated populations. University of Antwerp
Discovering novel somatic alterations in cancer using a full genome sequencing approach. KU Leuven
Understanding embryonic chromosome instability and the origins of structural genetic variation by genome sequencing of single blastomeres. KU Leuven
Although a cell produces an assortment of products that protect, inspect and if necessary heal its valuable genetic code, DNA-mutations can accumulate during a cell’s life cycle. This is exemplified by the acquisition of somatic genetic lesions that cause cancer, but also by the birth of disabled children due to a genomic aberration acquired during gametogenesis or early embryogenesis. In fact, most likely we all are genetic mosaics early on ...
LASTIG-FTD: Large-scale Application of Sequencing Technologies for Identifying Genomic factors in Frontotemporal Dementia University of Antwerp
Simultaneous detection of bacterial, fungal and oomycete plant pathogens by Nanopore sequencing of multiple genetic markers (Nanotect) KU Leuven
Microbial plant pathogens cause severe diseases and considerable yield losses in many economically important crops worldwide. Early detection and accurate quantification of pathogenic microorganisms are essential for effective disease management and to improve sustainability of agroecosystems. Although new detection technologies have considerably improved over the years regarding accuracy and sensitivity, simultaneous detection of multiple ...
Novel neural networks for single-cell sequencing technologies Ghent University
Creating more expressive models of cells is a fundamental challenge in bioinformatics. Recently, single-cell sequencing has emerged as a way of characterizing biology with higher resolution, facilitating the construction of more comprehensive models. The technology has inherent limitations due to the lower amount of genetic material used, making the obtained data more noisy and incomplete. Current imputation and denoising methods fail to (1) ...
Culture-free approaches including whole genome sequencing in support of diagnostic and transmission studies on Mycobacterium leprae. University of Antwerp
Inter- and intra-community mapping of SARS-CoV-2 spread by combining whole-genome sequencing, phylogeographical analysis and movement traces Ghent University
Since the introduction of SARS-CoV-2, the virus has been spreading very rapidly and has caused severe respiratory pathology around the world. A pandemic ensued within a short time. The virus originated from a zoonotic event, where likely a bat or even a pangolin was carrying the virus and infected a human by animal-to-human transmission. This means that the virus is still seeking an optimal fit with its new host, the human. This is, for ...
Inter- and intra-community dynamics of SARS-CoV-2 spread by whole-genome sequencing and phylodynamic analysis KU Leuven
Since the introduction of SARS-CoV-2, the virus has been spreading
very rapidly and has caused severe respiratory pathology around the world. A pandemie ensued within
a short time. The virus originated from a zoonotic event, where likely a bat or even a pangolin was
carrying the virus and infected a human by animal-to-human transmission. This means that the virus
is still seeking an optimal fit with its new host, the ...