Infrastructure
Platform for Next Generation Screening in Quantitative Biology & Drug Discovery (NEXTGEBQBIO) KU Leuven
In this proposal we outline a state-of-the-art platform that would be among the first in Europe to combine the best in automated microscopy with advanced cell culture robotics capable of automated isolation, expansion and differentiation of mammalian and human cells, including iPSC. The platform will be unique in Flanders and will allow running quantitative image-based screens as well as screens for disease phenotypes using conventional cell lines but more importantly also on human stem cells, which provide the closest mimic of human pathology currently available. Not only will this prove ...
An high-throughput automated small molecule screening platform (SMC) KU Leuven
The desired equipment consists of a robotic sampler that enables the automated sample preparation of large cohorts, followed by the analysis of the samples onto a high-throughput mass spectrometer capable of analyzing hundreds to thousands of samples per day.
Multi-mode reader. KU Leuven
A modular, upgradable multi-mode reader for 6- to 384-well microplates that can measure over time fluorescence, absorbance from UV and through the visible light range, and luminescence. The system operates with flexible
monochromator-based optics that provides a bandwidth of 230 - 999 nm with about 2 nm accuracy. The system further can use filter-based optics which provide very high sensitivity at the cost of some flexibility.
To facilitate measurements over time, for example fluorescence or absorption measurements on living cells, the reader provides accurate incubation up to 45 ...