Development of modified anhydrohexitol nucleic acid (HNA) and altritol nucleic acid (ANA) antisense oligonucleotides to combat SARS-CoV-2 KU Leuven
Since the emergence of SARS-CoV-2, the cause of COVID-19, this pandemic virus has been a major global concern due to frequent appearance of variants that are highly transmissible and capable of evading the vaccine-elicited immune response. Antiviral drugs with high efficacy against multiple coronaviruses or variants are urgently needed to control the COVID-19 pandemic and future outbreaks by novel coronaviruses. Antisense oligonucleotides ...