Projects
Can food additives cause liver damage? A mechanistic in vitro modelling study. Vrije Universiteit Brussel
safety of food additives. Among those are a number of colourants,
sweeteners, anti-caking or glazing agents that have been shown to
cause adverse effects in the liver of laboratory animals. The present
project will elucidate the mechanisms underlying these presumed
hepatotoxic effects by incubation of these food additives in
tridimensional ...
The development and validation of a prototype of a Belgian data registration system on medication use during pregnancy and lactation (BELpREG-project) KU Leuven
Promoting intestinal health by modulating the Zinc-microbiome axis at the Paneth cell level Ghent University
Development, characterization and validation of an in vitro/in silico platform to predict transfer of medicines to human breast milk along with neonatal systemic exposure to maternal medication. KU Leuven
Breastfeeding has been shown to have short- and long-term benefits regarding chronic diseases, cognitive deficits, infant morbidity and mortality. However, breastfeeding adherence in the EU is low. One of the factors leading to the decision not to breastfeed is the lack of safety information for medicines. It is currently impossible to make evidence-based decisions on the use of maternal medication during breastfeeding. Women are counselled ...
Towards novel therapeutic strategies in ischemic stroke by targeting von Willebrand factor and promoting fibrinolysis KU Leuven
Ischemic stroke is worldwide the second most common cause of death and the leading cause of permanent disability. In order to improve therapeutic and prophylactic therapy, it is imperative to understand what causes ischemic stroke and how ischemic stroke brain damage progresses. Up until recently, little was known about the thrombi that cause ischemic stroke. Moreover, experimental and clinical data have demonstrated progression of ischemic ...
BACCHUS Project Ghent University
In the Bacchus project, bioactive peptides and polyphenols will be used to design a new platfrom combining in vitro digestion with an in vitro transportmodel (Caco-2). Bioavailability and bioactivity of the obtained metabolites are thereby the main focus. In parallel, in vivo studies will be performed by project partners to validate the in vitro model.
Development of novel anti-inflammatory strains to counterbalance dysbiosis in inflammatory bowel disorders Ghent University
The link between the intestinal microbiota and gut inflammation in IBD in humans and NE in poultry supports selective manipulation of the microbiota composition as a therapeutic strategy. Butyrate producing bacteria have significant anti-inflammatory potential due to production of butyrate and other extracellular compounds. The aim is to investigate anti-inflammatory properties of newly isolated butyrate producing bacteria to use for ...
RT 20/4 ALTERTOX - Towards risk assessment of Alternaria mycotoxins: comparative in vitro toxicity, and in vivo toxicokinetics in pigs as surrogate animal model for humans Ghent University
ALTERTOX aims to clarify following research questions:
- What is the in vitro cytotoxicity of alternariol, alternariol-monomethylether, tenuazonic acid and relevant mixtures thereof towards intestinal epithelial cells and hepatocytes of human and porcine origin? This will enable the calculation of the mycotoxin concentration at which 50% of the cells show loss in viability (EC50 endpoint), and to determine the ...
A Belgian policy framework for best-value biological medicines KU Leuven
Biological medicines (biologicals) represent a growing share of all medicines worldwide. Biologicals are complex molecules produced out of cultures of living cells. Biologicals are becoming increasingly important in the treatment of diverse complex, life-threatening disorders, and chronic illnesses. However, due to the complex and costly manufacturing process, biologicals are in general very expensive. The success of biological therapies has ...