Intestinal organoids as models for the development of antivirals against human norovirus and rotavirus. KU Leuven
The project will investigate viral replication assays in gut organoids towards their use in exploring novel antiviral strategies to combat noro- and rotavirus infections. The major limitation to develop novel small molecule inhibitors for human noro- (HuNoV) and rotaviruses (HRV) is the lack of a robust in vitro or in vivo culture model. Gut organoids will be implemented to study infection and replication of multiple HuNoV and HRV strains. ...