Projects
DOLORisk: Understanding risk factors and determinants for neuropathic pain Ghent University
Neuropathic pain (NP) is common (population prevalence of 7-8%) and will present a rising health burden in the future. NP results in significant morbidity, reduces quality of life and has a major deleterious impact on health in aging. The reason why some subjects develop neuropathic pain and others do not following the same injury is not
known. The exact nature of risk factors for NP and their interaction are currently poorly understood ...
Personalised Medicine by using an Advanced Point-of-Care Tool for Stratified Treatment in High Risk Cardiovascular Patients Ghent University
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Besides established risk factors such as elevated blood pressure, blood glucose or lipid levels, circulating proteomic as well as genetic markers allow further stratification of patients. While some of these markers can be measured routinely in low-threshold healthcare institutions, others require access to highly specialized and costly laboratory environment which ...
A PeRsOnalized Prevention roadmap for the future HEalThcare KU Leuven
PROPHET - a PeRsOnalized Prevention roadmap for the future HEalThcare"" will develop a Strategic Research and Innovation Agenda (SRIA) for Personalized Prevention, in order to support the implementation of innovative, sustainable and effective personalized programmes to prevent common chronic diseases. Technological biomedical advances (including omics data and digital tools) make risk stratification at the individual level possible. However, ...
Paediatric Inflammatory Bowel Diseases Network for Safety, Efficacy, Treatment and Quality improvement of care (PIBD-SETQuality) Vrije Universiteit Brussel
B-specific: B-cell related gene and protein markers with prognostic and therapeutic value for CVD KU Leuven
Atherosclerosis is the major underlying condition of cardiovascular disease (CVD) and one the leading causes of mortality. Rupture or erosion of atherosclerotic lesions can lead to acute cardiovascular events, such as myocardial infarction and stroke, making biomarkers to diagnose patients at risk for these events and develop tailored preventive interventions, an urgent need. Although atherosclerosis is a chronic inflammatory disease, ...
Biomarkers affecting the transition from cardiovascular disease to lung cancer: towards stratified interception. KU Leuven
Cardiovascular disease (CVD) and lung cancer (LC) are leading causes of deaths and intertwined chronic inflammatory processes associated with metabolism reprogramming, clonal hematopoiesis of indeterminate potential (CHIP), intestinal dysbiosis, and maladaptive immunity. CVD prone-tobacco users exhibit a 1-2% yearly incidence of LC. Low dose computed tomography screening programs reduce LC mortality by 20%. Beyond epidemiological scores, risk ...
CoroPrevention : Personalized Prevention for Coronary Heart Disease Hasselt University
Urinary PROteomics in Predicting HEart Transplantation outcomes KU Leuven
The proof of concept underlying uPROPHET rests on the EPLORE findings that capillary electrophoresis coupled with high-resolution mass-spectroscopy reproducibly identified unique urinary proteomic (UP) signatures associated with subclinical left ventricular dysfunction, renal impairment and adverse cardiovascular outcomes. Consensus criteria currently applied for the selection of patients for heart transplantation (HTx) leave an inconvenient ...
Methods in Research on Research Ghent University
Our aim is to create, in Europa, an innovative and ambitious multidisciplinary intersectoral joint doctoral training programme, dedicated to Methods in Research on Research (MIROR) in the field of clinical research."research on Research", is an emerging new scientific discipline that aims to reduce waste in research and increase research value. waste in research represents tens of billions of Euros spent each year on studies that are ...