Projects
Multiscale Modeling of the Respiratory System in the Context of Acoustic Diagnostics KU Leuven
Detection and identification of non-linear characteristics in the respiratory impedance Ghent University
This research proposal aims to correlate the nonlinear contributions present in systems, with the class of models known as generalized-order models (fractional-order models). The proposal enables the possibilities to extract information from nonlinear systems by means of detection and quantification of the nonlinear contributions in a generalized context. The envisaged methods are based on specific signal design and specific signal ...
Visualisation of inspiratory effort and respiratory mechanics to promote lung-and diaphragm protective ventilation. University of Antwerp
Detection and identification of nonlinear properties in the respiratory impedance Ghent University
This research proposal aims to correlate the nonlinear contributions present in systems, with the class of models known as generalized-order models (fractional-order models). The proposal enables the possibilities to extract information from nonlinear systems by means of detection and quantification of the nonlinear contributions in a generalized context. The envisaged methods are based on specific signal design and specific signal processing ...
Mapping airflow dynamics and its immunological correlate on a single cell level in CLAD KU Leuven
One part of the research encompasses the analysis of airflow in chronic lung allograft dysfunction (CLAD), using Computational Flow Dynamics (CFD) modeling. Models can help to link morphologial changes in the lung to the experienced symptoms and health of the patiënt. Models will also allow to study how theoretical changes in tissue elasticity (reflecting the changes observed in COPD and ILD) may affect local flow and pressure during ...
The roll of regulatory cells in rejection post lung transplant KU Leuven
Chronic lung allograft dysfunction (CLAD) continues to pose a significant challenge to long-term survival after lung transplantation. CLAD is a complex condition caused by a multifactorial process with alloimmune-dependent and -independent factors. Alloimmune-dependent factors are related to the alloimmune response from the recipient directed against the ‘nonself’ donor, referred to as allograft rejection. The objective of this PhD project ...
Multimodal Signal Analysis for Unobtrusive Characterization of Obstructive Sleep Apnea KU Leuven
Obstructive sleep apnea (OSA) is the most prevalent sleep related breathing disorder, nevertheless subjects suffering from it often remain undiagnosed due to the cumbersome diagnosis procedure. Moreover, the prevalence of OSA is increasing and a better phenotyping of patients is needed in order to prioritize treatment. The goal of this thesis was to tackle those challenges in OSA diagnosis, by means of advanced signal processing algorithms, ...
Lung transplantation: impact and modulation of lung graft temperature during preservation and implantation KU Leuven
Lung transplantation is considered the ultimate treatment of end-stage lung failure. Despite progress in surgical and anaesthesiologic techniques, optimization of perioperative care, and improvements in immunosuppression, development of severe and life-threatening complications after lung transplantation remains a major obstacle. Ischemia and the process of graft rewarming after cold preservation are both considered to exert a major role in ...
Translational research on chronic rejection after lung transplantation. KU Leuven
Chronic lung allograft dysfunction (CLAD), the clinical correlate of chronic rejection, is the principal cause of late morbidity, mortality and excessive use of health-care resources following lung transplantation (LTx). Several allo-immune (e.g. acute rejection) and non allo-immune risk factors (e.g. air pollution, infection) are known to be involved in the onset of CLAD, yet the exact pathophysiological mechanisms, however, remain ...