Projects
Precision livestock farming meets metabolomics: an integrative approach to understand and quantify resilience in dairy cows, and to identify resilience biomarkers based on blood plasma and milk metabolites. KU Leuven
Resilience in animals and humans can be considered as their capacity to bounce back to normal status after a challenge. High resilience means better health and welfare and more efficient and sustainable performance, which is of high concern globally. In this study, the dairy cow around calving is applied as an animal model to quantify and improve the understanding of resilience. The combination of high-frequency phenotypic data obtained from ...
The role of desistance capital in the desistance process of Belgian cocaine couriers involved in the cocaine retail market: a multimethod approach Ghent University
The primary aim of this research is to gain insight in the desistance process of a specific and emerging group at the cocaine retail market namely the cocaine couriers. The research will focus on whether desistance capital, and more specifically the degree of personal, social and community capital, supports desistance among this specific group of offenders. In the last few years, the cocaine retail market has witnessed the emergence of new ...
The natural K, Fe, and Cu isotopic response to Pt-based chemotherapeutic drug resistance in ovarian cancer Ghent University
Cancer is the second leading cause of death globally and in the EU, and was responsible for an estimated one in six deaths in 2018. Early diagnosis plays an important role in determining cancer treatment outcomes, but the diagnosis of ovarian cancer poses significant challenges; the routine screening of asymptomatic average-risk women is not recommended by any professional society. Chemotherapy using Pt-based compounds (e.g. carboplatin, ...
Targeting lipid metabolism to overcome cancer therapy resistance KU Leuven
Targeting the DNA methylation profile of cytotoxic T cells to overcome immunotherapy resistance of pancreatic cancer KU Leuven
Overcoming resistance to anti-PD1 blockade in uterine leiomyosarcomas KU Leuven
Uterine leiomyosarcomas (uLMS) are rare tumors, characterized by an aggressive clinical behavior and high risk of hematologic spread. Currently, no highly effective therapeutic agents are available for these patients, which leads to a very poor prognosis and emphasizes the urgent need for new therapeutic options. The onset of immune checkpoint blockade (ICB) has transformed the therapeutic landscape in oncology, showing unprecedented ...
Understanding glutamate metabolism in the tumor microenvironment to tackle Immune Checkpoint Blockade (ICB) resistance KU Leuven
Despite the recent advancement in cancer treatment, this disease still remains a major medical burden. The most recent therapies aim to reactivate the patient's immune system to recognize and fight the cancer cells. Such therapies have been proven extremely effective leading to strong remission, but a significant proportion of patients show resistance to such approaches and cannot profit from such an advanced medical care. In this proposal we ...
Investigation of Crack resistance and Healing in BITuminous materials (CrasHBIT) University of Antwerp
The role of aberrant splicing in apoptosis and therapy resistance in T-cell leukemia Ghent University
Acute Lymphoblastic Leukemia (ALL) is an aggressive blood cancer with survival rates of only 50%. Especially high-risk and relapsed disease cases present with poor prognoses. Current frontline therapy includes DNA damaging chemotherapy and glucocorticoids. However, as only 15-20% of all relapsed ALL cases present with new genetic alterations, various non-genetic mechanisms have arisen recently at the forefront of therapy research. Among ...