Projects
The intimate link between hepatitis C virus and the host lipid metabolism as a potential target for inhibition of viral replication. KU Leuven
Role of receptor tyrosine kinases and associated gangliosides in influenza virus replication KU Leuven
Influenza infections produce significant medical and socio-economic burden. Every year, human influenza A and B viruses cause millions of cases of severe respiratory illness and death. Every so often, a pandemic arises when a zoonotic influenza A virus with sustained human transmissibility enters the human population. Antivirals are crucial for influenza treatment and prevention, especially in fragile populations such as elderly. At the ...
Replication of in vivo maturation environment in vitro to reduce chromosomal aberrations Ghent University
Although oocyte in vitro maturation (IVM) has undergone significant advancements, the systems that are currently in place still need to be further optimized. This project aims to develop an improved culture system for oocyte IVM able to reduce the frequency of polyspermy, which is one of the main causes of chromosomal aberrations in embryos produced in vitro.
JPI Urban Europe: Citizen inclusive PEDs in 4 existing urban areas, implementation and certification as replication Vrije Universiteit Brussel
Particular attention is paid to the involvement of citizens, considered the main
success factor for the long-term ...
Dual targeting of nsp12 and nsp15: a powerful concept to suppress coronavirus replication and transcription KU Leuven
Identifying the governing principles and mechanisms of the subcellular organization of bacterial replication KU Leuven
Bacteria are small unicellular organisms that often exhibit short generation times, are genetically tractable and easily engineerable. Although bacteria represent simple forms of proliferating cells, without additional layers of internal organization (e.g., membrane-enclosed organelles) or cell cycle regulation (e.g., cyclins and cyclin-dependent kinases) seen in eukaryotic cells, they too need to spatially organize their cellular content to ...
Deep single-cell phenotyping to identify governing principles and mechanisms of the subcellular organization of bacterial replication KU Leuven
Modern metagenomics has opened our eyes to the immense bacterial diversity that exists both among and within us. Despite this diversity, all bacteria share the basic challenge of organizing the various processes that ensure their faithful replication. All bacterial cells need to metabolize nutrients, generate building blocks, maintain their shape and size, replicate and segregate their chromosomes, synthesize cell walls and membranes, and ...
Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma (REINFORCE) Ghent University
This study aims to identify and explore novel therapeutic targets for combination therapy and immunomodulation in neuroblastoma, a pediatric tumor of the developing peripheral nervous system. The teams will collaboratively apply novel technology in functional cancer genetics, oncoimmunology, animal modeling and liquid biopsy analysis. This program will yield novel therapeutic strategies with better survival and reduced adverse side ...