Projects
Non-invasive assessment of functional, cellular and molecular mechanisms linking inflammation and cardiac remodeling after acute myocardial injury. KU Leuven
Ischemic heart disease is a leading cause of death. The metabolic, functional, cellular and structural changes after acute myocardial injury, also termed cardiac remodeling, determine residual cardiac function, development of heart failure, and survival. Acute/chronic inflammation and reperfusion not only contribute to infarct healing but paradoxically also cause aggravation of the injury. Type, extent and timing of post injury events will ...
Studying the impact of modulated inflammation in cardiac ischemia reperfusion injury. KU Leuven
Ischemic heart disease is a leading cause of death. The metabolic, functional and structural changes after acute myocardial injury, also termed cardiac remodelling, determine residual cardiac function, development of heart failure and survival. Inflammation and reperfusion not only contribute to infarct healing but paradoxically can also cause aggravation of the injury (metaflammation). Ischemic postconditioning has shown its beneficial role ...
In vivo study of cardiac function and inflammation after ischemia/reperfusion KU Leuven
The role of micro-RNA -221 and -222 in the pathophysiology of viral myocarditis KU Leuven
Introduction and background
Viral myocarditis is a major health problem: up to 40% of sudden death in young people is due to myocarditis – adverse inflammation – in the heart (1). A lot of viruses can cause myocarditis, but especially rhinoviruses and enteroviruses are responsible pathogens (2).
Cardiac inflammation plays a central role in myocarditis and heart failure, mediating cardiac hypertrophy, myocyte death and fibrosis. ...