Synthesis and (pre)clinical evaluation of PET radioligands for in vivo visualization of phosphodiesterase 10, an enzyme involved in neurological and psychiatric disorders. KU Leuven
Several compounds have been evaluated in cooperation with Johnson & Johnson as PET radioligands for the in vivo visualisation of the PDE10A enzyme, which is highly expressed in the striatum and the pharmacological characterisation of which indicates a potential use of PDE10 inhibitors for treating neurological and psychiatric disorders like schizophrenia. The availiability of PET radioligands for the in vivo visualization of PDE10A is ...