Projects
A NOVEL TOOL TO PREDICT CONTINENCE OUTCOMES IN PATIENTS OPTING FOR RADICAL PROSTATECTOMY AND IN THOSE UNDERGOING SURGERY FOR INCONTINENCE. KU Leuven
This project aims at generating reliable and evidence based tools to predict incontinence recovery after prostatic surgery. Moreover we aim also at creating new tools to counsel incontinent patient on the best treatment for their incontinence
Urinary incontinence and erectile dysfunction after radical prostatectomy: longitudinal evolution and the effect of intensive treatment for erectile dysfunction minimum one year after surgery. KU Leuven
Treatment of erectile dysfunction following cavernous nerve injury with adipose-tissue derived stem cells: efficacy and insights into the mechanisms of action of stem cell therapy. KU Leuven
Clinical and preclinical studies of modulators of high-risk prostate cancer with metastatic potential KU Leuven
The overarching aim of this dissertation is to contribute to both clinical and preclinical knowledge of high-risk localized prostate cancer (PCa).
It is currently accepted that high-risk PCa patients need radical treatment in an attempt to cure their disease. However, there are still important questions related to both oncological and functional outcomes that need to be addressed:
- Currently, the EAU PCa guidelines ...
The role of imaging in a patient-tailored approach for prostate cancer KU Leuven
New insights in the genomic architecture and treatment of high risk and oligometastatic prostate cancer KU Leuven
Prostate cancer (PCa) remains an important health issue as it is the second most frequent cancer diagnosis made in men and the fifth leading cause of death worldwide. Based on GLOBOCAN 2020 estimates, 1,414,259 new cases of prostate cancer were reported worldwide in 2020, with higher prevalence in the developed countries. PCa patients can be divided into 2 groups: localized or metastatic disease. Patients with localized disease are ...
Classical and non-classical actions of androgens and their receptor KU Leuven
Novel insights in the definition and treatment of high risk and oligometastatic prostate cancer KU Leuven
There is an urgent need to develop novel treatment strategies in the management of high-risk prostate cancer. These patients have a significantly elevated risk of disease recurrence and progression resulting in worse prognosis. To this end, the first objective of this thesis was to investigate the efficacy and tolerability of a novel second-line anti-androgen, apalutamide, prior to radical prostatectomy in high-risk PCa patients. The ...
Improvement of therapeutic management in patients with high-risk and oligorecurrent prostate cancer KU Leuven
The main subject will be to search for new targeted neoadjuvant therapies against prostate cancer. There has been positive effects seen of intensification of systemic treatments in advanced prostate cancer. Therapies from the non-curative setting are moving towards the curative setting. Although hormone therapies have been moved to the neoadjuvant setting, more intensified regimens with molecular markers have not yet been investigated. This ...