Publications
Bufotenine, a tryptophan-derived alkaloid, suppresses the symptoms and increases the survival rate of rabies-infected mice : the development of a pharmacological approach for rabies treatment Ghent University
Quantitative determination of the dissemination of Flury rabies virus in the central nervous system of the guinea-pig after intramuscular inoculation in the hind leg Institute of Tropical Medicine
Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers : a phase 1 trial Ghent University
Perceptions and practices of dog ownership and rabies control at a human-wildlife-domestic animal interface in South Africa Ghent University Institute of Tropical Medicine University of Antwerp
Factors influencing the immune response after a double-dose 2-visit pre-exposure rabies intradermal vaccination schedule: a retrospective study Institute of Tropical Medicine
Background: Double-dose 2-visit intradermal rabies schedules (22ID) have recently been accepted by the World Health Organization (WHO) as Pre-Exposure Prophylaxis (PrEP). The aim of this study is to determine which factors influence the levels of rabies virus neutralizing antibodies (RVNA) after a 22ID rabies vaccination schedule.
Methods: This is a retrospective study based on electronic health record vaccination data of subjects ...
Factors influencing the immune response after a single-dose 3-visit pre-exposure rabies intradermal vaccination schedule: a retrospective multivariate analysis Institute of Tropical Medicine
Background: The World Health Organization (WHO) recommends intradermal (ID) rabies vaccination as a safe and immunogenic alternative to intramuscular administration. The aim of this study is to determine which factors influence the levels of rabies virus neutralizing antibodies (RVNA) after a 3-visit ID rabies vaccination.
Methods: This is a retrospective secondary data analysis study based on electronic health record vaccination data ...
Redefining non-inferiority in anamnestic antibody responses using the mean increase of log-transformed antibody titers after revaccination: secondary analysis of a randomized controlled rabies vaccination trial Institute of Tropical Medicine
Non-inferiority in the anamnestic antibody response is conventionally determined by comparing seroconversion rates after revaccination. However, this approach is inadequate in the case of high pre-booster antibody titers. Therefore, we propose an alternative method to determine non-inferiority of booster responses. We used anonymized data from a randomized controlled trial (NCT01388985; EudraCT 2011-001612-62) in 500 adults, comparing a ...
Comparative immunogenicity and safety trial of 2 different schedules of single-visit intradermal rabies postexposure vaccination Institute of Tropical Medicine University of Antwerp
Background: Effective and safe single-visit rabies vaccination for pre- and postexposure prophylaxis (PrEP and PEP) could substantially simplify rabies prevention and therefore increase compliance.
Methods: In a comparative trial, 303 healthy adults received a primary vaccination that consisted of 2 intradermal (ID) doses of 0.1 mL of the purified chicken embryo cell vaccine (PCEV) during a single visit. One year later, participants ...
Epidemiology, impact and control of rabies in Nepal Institute of Tropical Medicine Ghent University University of Antwerp
BACKGROUND: Rabies is a vaccine-preventable viral zoonosis belonging to the group of neglected tropical diseases. Exposure to a rabid animal may result in a fatal acute encephalitis if effective post-exposure prophylaxis is not provided. Rabies occurs worldwide, but its burden is disproportionately high in developing countries, including Nepal. We aimed to summarize current knowledge on the epidemiology, impact and control of rabies in ...