Discovery, initial hit-optimization and mechanism of action of novel inhibitors of enterovirus. KU Leuven
Enteroviruses are non-enveloped, single-stranded positive-sense RNA viruses which belong to the family of Picornaviridae. Enteroviruses are important emerging pathogens and dangerous disease-causing agents for newborns and children worldwide, for which no vaccine or antiviral drugs are available. The overall aim of my Ph.D project is to discover and develop active compounds against one or more enteroviruses. We use enterovirus 71 ...