Projects
Single cell RNA and small non-coding RNA sequencing to identify biomarkers for pathogenesis and therapy response in type 1 diabetes. KU Leuven
Type 1 diabetes (T1D) is an autoimmune disease resulting from T-cell mediated destruction of the pancreatic beta-cells causing blood glucose dysregulation. We devised a unique method for tolerance restoration in autoimmune diabetic mice using gut delivery of bacteria genetically altered to secrete proinsulin along with the immunoregulatory cytokine IL10. To facilitate clinical translation, profound insights in the mode of action and the ...
Pan-cancer liquid biopsy screening for the identification of actionable RNA biomarkers Ghent University
The biggest challenges in cancer patient management are the use of more effective and less toxic treatmant modalities, better and less invasive methods to diagnose disease, to select the right drug, to monitor treatment response and to identify relapse disease early-on. Our project proposal aims to address several of these issures by the introduction of RNA based liquid biopsy guided precision oncology. We will screen easy-to-obtain plasma ...
RNA biomarkers discovery for ultra-fast drug synergy and susceptibility testing in the mycobacterium avium complex. University of Antwerp
Circulating tumor-derived RNA biomarkers: from bench to bedside Ghent University
Today, too many cancer patients are taking medicines that will not benefit them. This is partly due to the fact that genetic differences among tumors cause differences in the efficacy of the same drug, resulting in cure for some patients, while others do not respond to the therapy. As such, researchers aim at mapping the biological characteristics of each cancer patient, in order to
determine the drug that will work best for the ...
Unraveling the potential of circular RNAs as novel biomarkers of radiation exposure and- sensitivity and their functional characterization in the radiation response University of Antwerp
A mucin mRNA isoform-based biomarker assay to improve treatment response in patients with inflammatory bowel diseases. University of Antwerp
Automation of a mucin mRNA isoform-based biomarker platform to monitor patients with inflammatory bowel diseases. University of Antwerp
A DNA methylation signature as biomarker for prognosis in children with neuroblastoma Ghent University
We wish to validate a DNA methylation prognostic classifier that can differentiate between high-risk and low-risk neuroblastoma patients. To select candidate markers, MBD2-sequencing will be performed on primary tumor samples, combined with an integrative analysis of earlier research results. Using MSP, these markers will then be validated in independent patient sets and on patient bone marrow and serum samples.