Necroptotic proteins in diseases: targeting RIP kinases in inflammatory disorders and exploring the role of MLKL in melanoma development Ghent University
RIPK1 and RIPK3 are both kinases that belong to the subfamily of Ser/Thr Receptor-Interacting Protein Kinases (RIPK) within the tyrosine kinase-like family. These kinases are crucial mediators of inflammation, regulated cell death (necroptosis and apoptosis) and survival. Two aspects of RIPK1 will determine cellular fate: RIPK1 kinase activity initiates apoptosis or necroptosis upon activation, the latter occurring in caspase-8 deficient ...