Projects
Bead-enabled capturing and fluorescent labeling to quantify direct respiratory virus-microbiota interactions. University of Antwerp
Deciphering mechanisms of respiratory virus-induced asthma predispositions and exacerbations. Ghent University
In Western countries, the prevalence of asthma has increased during the last decades. Although asthma is often non-lethal, the quality of life of patients is seriously affected and there is still no definitive cure available. It is clear that the environment has a dramatic impact on the incidence and the severity of allergy and asthma, and a strong link between respiratory tract infections and asthma has been demonstrated, with some viruses ...
Targeting the modified innate functionality of the post-asthma alveolar macrophage for relieving Respiratory Syncytical Virus-induced astham exacerbation. Ghent University
Alveolar macrophages residing in the bronchoalveolar lumen of the lungs exhibit after an allergic asthma phase a modified functionality, featuring an increased inflammatory responsiveness to Respiratory Syncytial Virus (RSV) infection, yet exhibit an unaltered antiviral defense. This uncoupling of inflammatory and antiviral responsiveness may well be at the origin of RSV-induced asthma exacerbation and promises a new therapeutic opportunity ...
Dengue virus infection of endothelial cells: Pathogenesis and antiviral potential of glycosaminoglycan targeting KU Leuven
Dengue viruses (DENV) are single-stranded positive-sense RNA viruses that belong to the family of the Flaviviridae, together with other important human pathogens (e.g. yellow fever virus and West Nile virus). Dengue is currently considered to be the most important arthropod-borne vial disease in humans. Four genetically distinct, but serologically related serotypes (DENV 1-4) are transmitted to humans by mosquitoes of the ...
The stride towards health economic evaluation with individual-based models integrating transmission dynamics, stochasticity and uncertainty. University of Antwerp
Preparing for RSV Immunisation and Surveillance in Europe (PROMISE). University of Antwerp
Elucidating the mechanism of action of small molecule replication inhibitors of RSV and hMPV. University of Antwerp
Investigating itaconic acid as a critical immunometabolite in Influenza and RSV infections Ghent University
Influenza viruses are a major public health threat. Also respiratory syncytial virus (RSV) is a major cause of severe respiratory disease. In this project, we will focus on the role and importance of the metabolite itaconate as an anti-inflammatory protective mechanism induced by activated myeloid cells during Influenza and RSV infections. With this, we aim to understand the process of metabolic ‘reprogramming’ in myeloid cells in the context ...