Projects
Breaking cancer drug resistance: exploring drug resistance mechanisms to exploit associated vulnerabilities KU Leuven
Resisting resistance: WWII resistance movements as milieux de mémoire in post-war Belgium (1945-present) Ghent University
The Second World War in Belgium is remembered personally and locally, in different and often
contrasting ways. Internationally, the Belgian memory landscape has therefore been pointed out
as a unique case study, not only because of the plurality of war memories, but especially for the
lack of national attention for the victors of the war: resistance fighters. Notwithstanding the
political usage of resistance legacy by ...
Technical Assistance to the second nationwide Tuberculosis Drug Resistance Survey in Bangladesh from 2018 to 2019 Institute of Tropical Medicine
Request for assistance in development of statistical analyses of methods for evaluation of data on antimicrobial resistance in zoonotic agent isolates from animals and food. Hasselt University
Technologies for removal of antibiotic resistant bacteria and antibiotic resistance genes from sewage sludge KU Leuven
Excessive use of antibiotics in addressing both human and animal ailments lead to their discharge to the environment. This facilitates increased exposure of microbes to antibiotics and the spread of Antibiotic Resistant Genes (ARGs) in soil, groundwater, surface water and sediments. One such exposure, especially of bacteria to antibiotics at very high concentration is prevalent in effluent water and sludge from wastewater treatment plants ...
Exploiting acquired vulnerabilities in fatty acid metabolism to overcome therapy resistance in castration resistant prostate cancer KU Leuven
Castration resistant prostate cancer (crPCA) remains refractory to
androgen deprivation therapy (ADT) and is invariably lethal. Therefore,
strategies in extending therapy response or overcoming therapy
resistance are sorely needed. Based on solid evidence that androgen
signalling drives fatty acid synthesis, rendering membrane lipids more
saturated and contributing to therapy resistance, we propose to exploit ...
Identification of drug resistance mechanisms and acquired sensitivities in resistant cancer cells using genome-wide CRISPR-mediated screens KU Leuven
Multidrug resistance is a major issue in the cancer field. To counter this problem, extensive research unravelling the molecular mechanisms underlying multidrug resistance is highly needed. This enables the discovery of biomarkers and facilitates the identification of novel drug targets. For this purpose, genome-wide CRISPR screens, based on gene activation and gene knock-out, will be implemented. In this way, resistance mechanisms to ...
Antibiotic residues, antibiotic resistant bacteria and antibiotic resistance genes in manure, soil and plants and the potential exposure of humans Research Institute for Agriculture, Fisheries and Food
When livestock manure is used on agricultural land, in addition to the known attention to environmental problems, concern is increasing about antibiotic residues and antibiotic resistance genes that may end up in the environment with the manure. In this project we investigated the impact of manure with antibiotic residues and resistance genes. What do we observe in the agricultural soil on ...