Projects
Tandem Quadrupole mass spectrometer for accurate quantitative analysis of allergens and protein modifications in foods Ghent University
Tandem Quadrupole mass spectrometry is a basic tool for the quantitative analysis of specific molecules in complex matrices. The equipment will be used for proteomic research of foods, more specifically in the area of food allergens and the analysis of specific changes in proteins having an impact on food safety and food quality.
Qualitative and quantitative analysis of the antigenic epitopes of citrullinatend vimentin in rheumatoid arthritis Ghent University
In this project, we aim to identify citrullinated epitopes of vimentin in rheumatoid arthritis (RA) patients. Also the amount of citrullination will be quantified and the affinity of these epitopes with antibodies from serum or synovial fluid from RA patients. Additionally, a genetic study will be performed on the vimentin gene in these patients.
Development of genetically encoded biosensors for super-resolution optical fluctuation imaging KU Leuven
Life is dynamic, defined by the ability to maintain homeostasis in ever-changing environments. On a cellular level, this requires an intricate regulatory network to manage activities and reactivities in response to external stimuli. Fluorescence microscopy provides us a window into this dynamic realm of subcellular signalling. The complex spatiotemporal regulation of this network can be investigated with fluorescent indicators, remarkable ...
Microarrays for the phenotypic characterization of axenic cultures, bacterial mutants and microbiome communities Ghent University
In recent years, research into microbiomes has exploded. To comprehensively understand the dynamic structure of microbiomes and their interaction with (host) environments, tools which go beyond metagenomic profiling are deemed required.
One such unique perspective is offered by phenotypic profiling, which based on the cellular metabolism of living cells and cellular communities permit the high-throughput quantitative evaluation of ...
Proteomics Expertise Center Ugent Ghent University
The Proteomics Expertise center groups expertise in (quantitative analysis) of proteins, their post-translational modifications en their interactions using mass spectrometry technology. It shares it facilities with researchers who need proteomics for functional research on proteins in the broad application field of Life Sciences (biomedical, food, environment)
Characterization of the ACR4-AUR1/2-PP2A phosphorylation module in root growth Ghent University
The importance of the plant root system – which is taking care of indispensable plant functions such as uptake of nutrients and water, anchorage in the substrate and interactions with symbiotic organisms – is well-recognized (1). However, to maintain primary root growth and to create lateral organs, plants require coordinated (asymmetric) anticlinal and periclinal cell divisions followed by correct cell fate specification and cell ...
The study of the possible interactions between human Mas-related G Protein-coupled receptors. University of Antwerp
Super resolution fluorescence microscopy of biomolecular interactions with photochromic biosensors and complementation. KU Leuven
Fluorescence microscopy techniques are indispensable research tools that have enabled live cell imaging with low invasiveness, high sensitivity, and high spatiotemporal resolution. As a result, fluorescence microscopy has revolutionized our understanding of the inner workings of single cells and whole organisms. An integral part of the imaging performance is the fluorescent labels, as the quality of the labels influences the quality of the ...
Skin interaction of the cyclic depsipeptide mycotoxins Ghent University
This research project quantitatively characterises the interaction of cyclic depsipeptides (CDP) with human skin using ex-vivo in-vitro FDC experiments. This knwoledge is required for the global mycotoxin risk assessment due to skin-contact of contaminated cosmeceuticals, food, feed, indoor surfaces and airborne particles, but also for the development of topically applied new CDP-drugs, treating dermatological or systemic diseases after ...