Publications
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Game-based assessment: can games themselves act as assessment mechanisms? KU Leuven
Effective assessment of practical skills is a challenge for large-size classes. To reduce the time-consuming burden of staff members without compromising the quality of the assessment, a case study was set up to investigate whether games can be considered as suitable and valid tools for summative assessment. Using a traditional exam as bench-mark, a boardgame format was experimentally trialed to assess students' knowledge, skills and attitudes ...
Impairment of VGLUT2 but not VGLUT1 signaling reduces neuropathy-induced hypersensitivity KU Leuven
Glutamate is the major excitatory neurotransmitter in the central nervous system with an important role in nociceptive processing. Storage of glutamate into vesicles is controlled by vesicular glutamate transporters (VGLUT). Null mutants for VGLUT1 and VGLUT2 were poorly viable, thus, pain-related behavior was presently compared between heterozygote VGLUT1 and VGLUT2 mice and their respective wild-type littermates using a test battery that ...
Knockdown of the type 3 iodothyronine deiodinase (d3) interacting protein peroxiredoxin 3 decreases d3-mediated deiodination in intact cells KU Leuven
The type 3 iodothyronine deiodinase (D3) is the primary deiodinase that inactivates thyroid hormone. Immunoprecipitation of D3, followed by fluorescent two-dimensional difference gel electrophoresis and mass spectrometry, identified peroxiredoxin 3 (Prx3) as a D3-associated protein. This interaction was confirmed using reverse coimmunoprecipitation, in which pull-down of Prx3 resulted in D3 isolation, and by fluorescence resonance energy ...
Waarom seksualiteit enigmatisch blijft KU Leuven
Differential involvement of the extracellular 6-O-endosulfatases Sulf1 and Sulf2 in brain development, and neuronal and behavioral plasticity KU Leuven
The extracellular sulfatases Sulf1 and Sulf2 remove specific 6-O-sulfate groups from heparan sulfate, thereby modulating numerous signaling pathways underlying development and homeostasis. In vitro data has suggested that the two enzymes show functional redundancy. To elucidate their in vivo functions and to further address the question of a putative redundancy we have generated Sulf1 and Sulf2 deficient mice. Phenotypic analysis of these ...
Psychosocial mediators of a lifestyle physical activity intervention in women KU Leuven Ghent University
Objectives: A lifestyle physical activity intervention in women based on the transtheoretical model and social-cognitive theory effectively increased physical activity. The aim of the present study was to examine possible mediators (perceived benefits and barriers of physical activity, self-efficacy, processes of change, and social support) of these physical activity changes. Methods: Members of four units of a women's organization followed a ...
A commentary on national child maltreatment surveillance systems: Examples of progress. Vrije Universiteit Brussel
A commentary on national child maltreatment surveillance systems: Examples of progress.
Long-term cognitive deficits following posterior fossa tumor resection Vrije Universiteit Brussel University of Antwerp
The posterior fossa syndrome (PFS) consists of transient cerebellar mutism, cognitive symptoms, and neurobehavioral abnormalities that typically develop in children following posterior fossa (PF) tumor resection. The pathophysiological substrate of the syndrome remains unclear. We investigated eight children of whom five presented with a variety of clinically relevant non-motor language symptoms associated with cognitive and behavioral ...