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Infrastructure for Targeted Proteomics KU Leuven

Tatiana Kouznetsova
Hypertension and Cardiovascular Epidemiology, Allergy and Clinical Immunology Research Group, Digestive Oncology, Translational Research in GastroIntestinal Disorders, Adaptive Immunology, Nephrology and Renal Transplantation Research Group, Immunobiology (Rega Institute), Research Group for Rehabilitation in Internal Disorders
A large number of KU Leuven research groups are interested in using the Olink Signature Q100 system, which has unique features for high-throughput protein analysis. The Olink Signature Q100 Instrument is a dedicated benchtop system specifically designed and optimized for qPCR readout of the Olink Target 96, Target 48, and Focus panels based on the Proximity Extension Assay (PEA) technology. This technology is a game-changer for proteomics ...

PEA histone modification proteomics Ghent University

Filip Van Nieuwerburgh
Department of Pharmaceutics, Department of Data analysis and mathematical modelling

Olink's groundbreaking proteomics panels help scientists discover human protein biomarkers. Proximity Extension Assay (PEA) technology measures up to 1463 unique proteins in 88 samples simultaneously, starting from less than 3 microliters from nearly any type of biological sample. Unique application domains are located where mass spectrometry (MS) based proteomics is suboptimal. Samples such as cerebrospinal fluid (CSF), microdialysis ...

Anti-ADAMTS13 antibodies: Essential tools to explore the ADAMTS13 structure/function and diagnose thrombotic thrombocytopenic purpura KU Leuven

Karen Vanhoorelbeke
Chemistry, Kulak Kortrijk Campus, Mechatronics, Biostatistics and Sensors (MeBioS), Cardiovascular Sciences, Kulak Kortrijk Campus

By regulating the proteolysis of von Willebrand factor (VWF), the plasma enzyme ADAMTS13 (A Disintegrin And Metalloproteinase with ThromboSpondin type-1 repeats, member 13) supports the balance between hemostasis and thrombosis. Hereto, the activity of ADAMTS13 is strictly regulated by structural features that appear unique within the ADAMTS enzyme family. Upon severe ADAMTS13 deficiency, persistent ultra-large VWF multimers can ...

Harnessing transcriptome and proteome wide analyses and engineered reporter assays to unravel the immunopathogenesis of 'multisystem inflammatory syndrome in children' (MIS-C). Ghent University

Rudi Beyaert
Department of Biomedical molecular biology, Department of Internal Medicine and Pediatrics

In rare instances, pediatric SARS-CoV-2 infection results in 'multisystem inflammatory syndrome in children' (MIS-C). To date, the pathophysiology of this novel hyperinflammatory disease is only partly understood. We enrolled 37 MIS-C patients in a multi-centric study in Belgium. Preliminary analyses comparing MIS-C patient with patients with severe COVID-19 reveal that MIS-C is associated with vascular endothelitis and gastrointestinal ...

Integrated computer modelling of cardiorespiratory fitness for personalised risk profiling and heart failure prevention (iCAREFIT) KU Leuven

Tatiana Kouznetsova
Cardiology, Research Group for Rehabilitation in Internal Disorders, Hypertension and Cardiovascular Epidemiology
Clinical exercise tests could improve the personalized risk profiling and management of cardiovascular disease. Yet, current practice only considers a limited selection of cardiopulmonary exercise indexes in isolation. To utilize the full value of clinical exercise testing data, we will apply advanced machine learning (ML) approaches on big data that has been collected/will be collected in patients at UZ Leuven (n=1800) and within the ...

CCR7 signalling and ligand bias: A comprehensive characterisation using label-based and label-free methodologies KU Leuven

Dominique Schols
Laboratory of Virology and Chemotherapy (Rega Institute)

G protein-coupled receptors (GPCR) are intricate transmembrane proteins that relay signals from the extracellular to the intracellular environment using heterotrimeric G proteins. GPCRs mediate a vast array of physiological functions, but when deregulated, they also contribute to many pathological diseases such as diabetes, Alzheimer’s disease, and cancer. This makes GPCRs an attractive therapeutic target. Indeed, approximately 35% of ...