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World Health Organization estimates of the global and regional disease burden of 22 foodborne bacterial, protozoal, and viral diseases, 2010 : a data synthesis Ghent University

Martyn D Kirk, Sara M Pires, Robert E Black, Marisa Caipo, John A Crump, Brecht Devleesschauwer, Dörte Döpfer, Aamir Fazil, Christa L Fischer-Walker, Tine Hald, et al.
BACKGROUND: Foodborne diseases are important worldwide, resulting in considerable morbidity and mortality. To our knowledge, we present the first global and regional estimates of the disease burden of the most important foodborne bacterial, protozoal, and viral diseases. METHODS AND FINDINGS: We synthesized data on the number of foodborne illnesses, sequelae, deaths, and Disability Adjusted Life Years (DALYs), for all diseases with sufficient ...

Multiplex PCR for bacterial, viral and protozoal pathogens in persistent diarrhoea or persistent abdominal pain in Côte d'Ivoire, Mali and Nepal Institute of Tropical Medicine

JK Jasuja, F Bub, J. Veit, H.K.M. Fofana, M. Sacko, R. Saye, J K Chatigre, E.K. N'Goran, Joel A Yao, B. Khanal, et al.
In contrast to acute diarrhoea, the aetiology of persistent digestive disorders (≥ 14 days) is poorly understood in low-resource settings and conventional diagnostic approaches lack accuracy. In this multi-country study, we compared multiplex real-time PCR for enteric bacterial, parasitic and viral pathogens in stool samples from symptomatic patients and matched asymptomatic controls in Côte d’Ivoire, Mali and Nepal. Among 1826 stool samples, ...

Repurposing auranofin and evaluation of a new gold(I) compound for the search of treatment of human and cattle parasitic diseases: from protozoa to helminth infections University of Antwerp

Liwen Feng, Sébastien Pomel, Perle Latre de Late, Alexandre Taravaud, Philippe M. Loiseau, Louis Maes, Fidelis Cho-Ngwa, Christina A. Bulman, Chelsea Fischer, Judy A. Sakanari, et al.
Neglected parasitic diseases remain a major public health issue worldwide, especially in tropical and subtropical areas. Human parasite diversity is very large, ranging from protozoa to worms. In most cases, more effective and new drugs are urgently needed. Previous studies indicated that the gold(I) drug auranofin (Ridaura®) is effective against several parasites. Among new gold(I) complexes, the phosphole-containing gold(I) complex ...

Screening of agelasine D and analogs for inhibitory activity against pathogenic protozoa; identification of hits for visceral leishmaniasis and Chagas disease University of Antwerp

Anders Vik, Ágnes Proszenyák, P. Loobuyck, Paul Cos, Louis Maes, Lise-Lotte Gundersen
There is an urgent need for novel and improved drugs against several tropical diseases caused by protozoa. The marine sponge (Agelas sp.) metabolite agelasine D, as well as other agelasine analogs and related structures were screened for inhibitory activity against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei and T. cruzi, as well as for toxicity against MRC-5 fibroblast cells. Many compounds displayed high general toxicity ...

Persistent SOMAtic Symptoms ACROSS Diseases - From Risk Factors to Modification: Scientific Framework and Overarching Protocol of the Interdisciplinary SOMACROSS Research Unit (RU 5211) KU Leuven

Omer Van den Bergh
INTRODUCTION: Persistent somatic symptoms (PSS) are highly prevalent in all areas of medicine; they are disabling for patients and costly for society. The subjective symptom burden often correlates poorly with the underlying disease severity, and patients' needs for effective treatment are far from being met. Initial evidence indicates that, in addition to disease-specific pathophysiological processes, psychological factors such as expectations, ...

Optimising patient active role with a user-centred eHealth platform (CONCERTO plus ) in chronic diseases management: a study protocol for a pilot cluster randomised controlled trial Vrije Universiteit Brussel

Mame-Awa Ndiaye, Alain Larouche, Guylaine Chabot, Christian Chabot, Ronald Buyl, Jean-Paul Fortin, Anik Giguère, Annie Leblanc, France Légaré

Introduction: Multimorbidity increases care needs and primary care use among people with chronic diseases. The Concerto Health Program (CHP) has been developed to optimise chronic disease management in primary care services. However, in its current version, the CHP primarily targets clinicians and does not aim to answer directly patients' and their informal caregivers' needs for chronic disease management. Various studies have shown that ...

The KIzSS network, a sentinel surveillance system for infectious diseases in day care centers: study protocol Institute of Tropical Medicine

Remko Enserink, Harold Noel, Ingrid H M Friesema, Carolien M de Jager, Anna M D Kooistra-Smid, Laetitia M Kortbeek, Erwin Duizer, Marianne van der Sande, Henriette A Smit, Wilfrid van Pelt, et al.

BACKGROUND: Day care-associated infectious diseases are widely recognized as a public health problem but rarely studied. Insights into their dynamics and their association with the day care setting are important for effective decision making in management of infectious disease control. This paper describes the purpose, design and potential of our national multi-center, day care-based sentinel surveillance network for infectious diseases (the ...